A history of anaphylaxis caused by neomycin would be a contraindication to receiving which of the following vaccines?

A history of anaphylaxis to neomycin is particularly relevant when considering the inactivated poliovirus vaccine (IPV). The IPV vaccine is produced using a combination of virus strains, and the production process can involve neomycin, which is an antibiotic that may be present as a residual in the final product. Therefore, individuals who have a documented history of anaphylaxis to neomycin have a contraindication to receiving IPV due to the risk of a severe allergic reaction upon administration.

In contrast, the other vaccines listed—Tdap (tetanus, diphtheria, and pertussis), PCV13 (pneumococcal conjugate vaccine), and HPV (human papillomavirus)—do not contain neomycin as a component in their formulations. While patients with a history of anaphylaxis should always be assessed carefully for potential allergic reactions, those specific vaccines would not pose the same risk associated with neomycin as IPV does.