Adolescents should be routinely vaccinated with MCV4 on the following schedule:

The recommended vaccination schedule for the meningococcal conjugate vaccine (MCV4) for adolescents is indeed 1 dose at age 11-12 years, followed by a booster dose at age 16 years. This schedule is in place to ensure that adolescents remain protected against invasive meningococcal disease, which is particularly important because the incidence of meningococcal disease can increase during the ages of 16-23 years.

The initial dose at 11-12 years is crucial as it provides early immunity during a time when immunity from childhood vaccinations may be waning. The booster dose at age 16 years is particularly important since teens are at increased risk of meningococcal disease, especially when entering college or communal living situations. The timing of the booster is strategically placed just before this period of increased risk.

This schedule is supported by guidelines from the Centers for Disease Control and Prevention (CDC) and aligns with national immunization recommendations. The other options do not follow this dual-dose schedule, which is specifically designed to ensure long-lasting protection during the highest risk years for adolescents.