How quickly must HZV be administered after reconstitution?

The herpes zoster vaccine (HZV), specifically Shingrix, must be administered soon after reconstitution to ensure its potency and effectiveness. Once the vaccine is mixed, it is advised that it be used within 30 minutes. This time frame is critical because the vaccine's viability diminishes after reconstitution due to the potential for degradation of its components.

Prompt administration within this half-hour window helps to maintain the effectiveness of the vaccine in producing an adequate immune response. While other time frames, such as 1 hour, 24 hours, or 72 hours, might initially seem plausible, they exceed the recommended period during which the vaccine should be utilized post-reconstitution. This highlights the importance of adhering to the specified timeline to ensure the patient's safety and maximize the vaccine's ability to provide protection against shingles.