What is the recommended routine schedule for vaccination against hepatitis B?

The recommended routine schedule for vaccination against hepatitis B consists of three doses: the first dose is given at 0 months (the time of initial vaccination), the second dose at 1 month, and the third dose at 6 months. This schedule is designed to ensure optimal immune response and long-lasting protection against hepatitis B virus infection.

The rationale behind this timing lies in the body's immune response to the vaccine. The initial dose primes the immune system, while the subsequent doses boost that response, enhancing the production of antibodies. Administering the final dose at 6 months ensures that the immune system has sufficient time to develop and sustain immunity over time, which is crucial for long-term protection against hepatitis B.

The other options do not follow this established and recommended timeline, which is essential for achieving effective immunity. Specifically, schedules that omit either the intermediate or late doses can result in suboptimal immunogenicity and may increase the risk of infection with hepatitis B.